tert-butyl (3-isothiocyanatopropyl)carbamate
N-Boc-3-异硫氰酰基丙胺
CAS: 286955-45-1
Molecular Formula: C9H16N2O2S
tert-butyl (3-isothiocyanatopropyl)carbamate - Names and Identifiers
tert-butyl (3-isothiocyanatopropyl)carbamate - Physico-chemical Properties
| Molecular Formula | C9H16N2O2S |
| Molar Mass | 216.3 |
| Density | 1.07±0.1 g/cm3(Predicted) |
| Melting Point | 67-72°C |
| Boling Point | 340.9±25.0 °C(Predicted) |
| BRN | 8202507 |
| pKa | 12.57±0.46(Predicted) |
tert-butyl (3-isothiocyanatopropyl)carbamate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42 - May cause sensitization by inhalation |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
tert-butyl (3-isothiocyanatopropyl)carbamate - Introduction
N-Boc-3-isothiocyanatopropylamine, full name N-tert-butoxycarbonyl-3-isothiocyanatopropylamine, is an organic compound. Its chemical formula is C10H18N2O2S.
Nature:
N-Boc-3-isothiocyanoyl propylamine is a colorless to pale yellow solid. It is stable at room temperature, but easy to decompose under high temperature or light. It will hydrolyze with water to produce isothiocyanate.
Use:
N-Boc-3-isothiocyanoyl propylamine is an important intermediate compound, mainly used in organic synthesis. It is commonly used in the preparation of peptides, amides, amino acids, imidazoles and other compounds. It has a wide range of applications in the pharmaceutical field, can be used as anti-cancer drugs, antiviral drugs and antibacterial agents.
Preparation Method:
The preparation of N-Boc-3-isothiocyanoyl propylamine is generally obtained by reacting chloro isothiocyanate (ISCN) with protected 3-aminopropanol (Boc-3-aminopropanol). This reaction needs to be carried out at low temperature under the protection of inert gas.
Safety Information:
N-Boc-3-isothiocyanatopropylamine has low toxicity to humans under normal operating conditions. However, it may have an irritating effect on the skin, eyes and respiratory tract. Appropriate protective equipment should be worn during operation to avoid direct contact. At the same time, keep the laboratory well ventilated and follow the relevant safety procedures.
Nature:
N-Boc-3-isothiocyanoyl propylamine is a colorless to pale yellow solid. It is stable at room temperature, but easy to decompose under high temperature or light. It will hydrolyze with water to produce isothiocyanate.
Use:
N-Boc-3-isothiocyanoyl propylamine is an important intermediate compound, mainly used in organic synthesis. It is commonly used in the preparation of peptides, amides, amino acids, imidazoles and other compounds. It has a wide range of applications in the pharmaceutical field, can be used as anti-cancer drugs, antiviral drugs and antibacterial agents.
Preparation Method:
The preparation of N-Boc-3-isothiocyanoyl propylamine is generally obtained by reacting chloro isothiocyanate (ISCN) with protected 3-aminopropanol (Boc-3-aminopropanol). This reaction needs to be carried out at low temperature under the protection of inert gas.
Safety Information:
N-Boc-3-isothiocyanatopropylamine has low toxicity to humans under normal operating conditions. However, it may have an irritating effect on the skin, eyes and respiratory tract. Appropriate protective equipment should be worn during operation to avoid direct contact. At the same time, keep the laboratory well ventilated and follow the relevant safety procedures.
Last Update：2024-04-09 21:11:58
